1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Aug 11, 1988 to Aug 25, 1988

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study performed using the commercial SAYTEX 8010 Flame Retardant as the test article and performed according to international guidelines and GLPs.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1988

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

2007

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)

Deviations:

no

GLP compliance:

yes

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]

EC Number:

284-366-9

EC Name:

1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]

Cas Number:

84852-53-9

Molecular formula:

C14H4Br10

IUPAC Name:

1,2,3,4,5-pentabromo-6-[2-(2,3,4,5,6-pentabromophenyl)ethyl]benzene

Details on test material:

The test article was the commercial flame retardant product.

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

Separate isolation by test system. Light cycle: 12 hr light, 12 hr dark. Temperature/humidity: maintained at 22°C ± 3°C and 30 to 70% humidity. Rats housed individually in cages sized in accordance with “Guide for the Care and Use of Laboratory Animals” of the Institute of Laboratory Resources, National Research Council. Waste material removed twice weekly. Cages and feeder sanitized every 2 weeks. Wayne Rabbit Ration, ad libitum, checked daily and added or replaced as needed. Fresh tap water ad libitum.

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

other: moistened with saline

Details on dermal exposure:

Test substance applied uniformly to shaved skin over an area approximating 10% of the total body surface area.

Duration of exposure:

24 hr

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5M/5F

Control animals:

no

Details on study design:

See Overall Remarks

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

None

Clinical signs:

other: None related to test article administration. One animal had diarrhea.

Gross pathology:

None

Other findings:

None

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

The dermal LD50 was greater than 2000 mg/kg bw.

Executive summary:

In a limit test, the test article was administered dermally to one group of 10 New Zealand White rabbits (5 males and 5 females) at a single dose of 2,000 mg/kg. The test material was held in contact with the skin under a wrapping for 24 hours. The rabbits were observed daily for 14 days. No clinical signs of test article-related toxicity were observed. None of the animals died during the study. No gross lesions were observed at necropsy.  The dermal LD50 was greater than 2,000 mg/kg.