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EC number: 231-853-9
CAS number: 7761-88-8
In vitro examination
- Viability measurements: after 4 hours of
incubation with silver acetate the number of dead cells was increased (5
fold) at a concentration of 5 µg Ag/mL. After 24 hours of incubation
with 5 µg Ag/mL, the number of dead cells was increased (12 fold) and
the number of living cells was decreased (3.5 fold). After 48 hours of
incubation, the number of dead cells exposed to 5 µg Ag/mL was increased
(23 fold) and the number of living cells was decreased after expsoure to
0.5 and 5 µg Ag/mL (2 and 12 fold, respectively). At 10 µg/mL, silver
acetate was highly cytotoxic.
- Necrosis detection: a
clear band of HMGB1 protein was seen in the positive control. After 24
hours of incubation, apoptosis, measured with TUNEl staining, was
observed in PC12 cells exposed to all doses of silver acetate, except
0.06 µg/mL. Silver acetate (1 µg/mL) apoptosis was inhibited by caspase
8 and 9 inhibitors. Neither the caspase 8 nor the caspase 9 inhibitor
affected the control level of apoptpsis observed.
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