2-dimethylaminoethyl methacrylate

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Original report is not available. However, the report is cited by a peer-reviewed OECD SIDS.

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

yes

Analytical monitoring:

yes

Vehicle:

no

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: water flea
- Source: National Institute for Environmental studies (Japan)
- Age at study initiation (mean and range, SD): < 24 h
- Feeding during test: no

Test type:

semi-static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Hardness:

30.3 mg/L

Test temperature:

19.7 - 20 °C

pH:

7.52 - 7.67

Dissolved oxygen:

8.43 - 8.93 mg/L

Nominal and measured concentrations:

Test concentrations (nominal): 18, 32, 56, 100, 180 and 320 mg/L
Test concentrations (measured): 10.5, 18.7, 29.7, 43.7, 70.4 and 119 mg/L

Details on test conditions:

TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 100 mL test solution in 100 mL glass beaker
- Renewal rate of test solution (frequency/flow rate): every 24 h renewal of the test solution
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4


OTHER TEST CONDITIONS
- Photoperiod: 16:8 h light-darkness cycle

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

33 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

18.7 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Measured concentrations of MADAME:

Nominal conc. (mg/L)	Measured conc. (mg/L)			Percent of nom.
	0 h (new)	24 h (old)	Mean
Control	N.D.	N.D.	N.D.	-
18	15	7.33	10.5	58
32	30.1	11.6	18.7	58
56	51.7	17.0	29.7	53
100	76.2	25.0	43.7	44
180	145	34.2	70.0	39
320	285	49.4	119	37

Mortality:

Nominal conc. (mg/L)
	24 h	48 h
Control	0	0
18	0	0
32	0	0
56	0	4
100	6	20
180	12	20
320	20	20

Description of key information

2-dimethylaminoethyl methacrylate is acute harmful to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

33 mg/L

Additional information

The acute toxicity of 2-dimethylaminoethyl acrylate to aquatic invertebrates was investigated in two studies. The MOE Japan (1997) reported an EC50 (48h) of 33 mg/L to Daphnia magna using a semi-static test system according to OECD guideline 202. In the second study an EC50 (48 h) of 53 mg/L was measured using the same species. Based on the results it can be concluded that with high probability 2-dimethylaminoethyl methacrylate is acute harmful to aquatic invertebrates.