Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Environmental health control for the rubber industry.
Author:
McCormick WE
Year:
1971
Bibliographic source:
Rubber Chem Technol, 44, 512-533.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data
GLP compliance:
not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on exposure:
Applications to the skin of rabbits in both dry and paste forms
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
no data
Frequency of treatment:
10 times
Doses / concentrations
Remarks:
Doses / Concentrations:
1000 mg/kg
Basis:
no data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No
Positive control:
No data

Examinations

Observations and examinations performed and frequency:
no data
Sacrifice and pathology:
no data
Other examinations:
no data
Statistics:
no data

Results and discussion

Results of examinations

Details on results:
No signs of systemic toxicity was observed ( no details).

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Ten repeated applications to the skin od rabbits at a dosage of 1000 mg/kg in both dry and paste forms did not produce signs of systemic toxicity.