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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference in Russian Documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Brief account of toxic properties of vulcanisation accelerators diphenylguanidine and furfuramide.
Author:
Arkhangel'skaya LN and Roshchina TA
Year:
1963
Bibliographic source:
Sovjet Rubber Tech. 22, 38-39.
Reference Type:
publication
Title:
No information
Author:
Arkhangel'skaya LN and Roshchina TA
Year:
1968
Bibliographic source:
Toksikol. Nov.Khim. Veshchesto, Vnedrialnik, Moskau, 117-126.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Remarks on MMAD:
MMAD / GSD: No data
Details on inhalation exposure:
no
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
15 days
Frequency of treatment:
2 h/day
Doses / concentrations
Remarks:
Doses / Concentrations:
ca. 0.22 mg/l
Basis:
no data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
no
Positive control:
no data

Examinations

Observations and examinations performed and frequency:
no data
Sacrifice and pathology:
no data
Other examinations:
no data
Statistics:
no data

Results and discussion

Results of examinations

Details on results:
Symptoms of toxicity: marked disturbance in the intensity of oxidation-reduction processes; functional changes of nervous system; blood pressure rose briefly (for several days) and fell than to lower levels than the initial values (no details reported)

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion