Registration Dossier
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EC number: 201-250-5 | CAS number: 80-09-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Short -term toxicity
Short-term ecotoxicity data for freshwater at three trophic levels are available. The acute toxicity test showed that Daphnia is the most sensitive species with a EC50 of 55 mg/L.
The LC50 (96 h) to fish was indeed determined to be above the limit dose of 100 mg/L.
In a growth inibition test conducted with the green algae Desmodesmus s. an EC50 (72 h) of 106 mg/L and a NOEC of 10.2 mg/L were derived.
Long-term toxicity
A NOEC (21 d) of 2.7 mg/L was derived in a reproduction test conducted with Daphnia magna.
A range finding early life stage test was conducted to assess the effects of DHDPS on the most critical and sensitive life-stages of a freshwater fish zebrafish (Danio rerio) and to target test concentrations for a definitive extended one generation reproduction test.
A NOEC for survival of ≥ 10 mg/L was derived. For growth impairment the NOEC was ≥ 10 mg/L
Recent published screening studies with zebrafish (Naderi et al., 2014 and Ji et al., 2013 - see section 6.6 of substance dossier) have investigated potential adverse effects of 4,4'-sulphonydiphenol on the endocrine system in fish. A final assessment in the technical dossier is pending but will be completedin the course of the substance evaluation (REACH) process currently carried out by MSCA Belgium.
Activated Sludge
The EC10 of the test substance to activated sludge was tested to be 200 mg/L.
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