Registration Dossier
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EC number: 201-250-5 | CAS number: 80-09-1
Endpoint summary
Administrative data
Description of key information
Additional information
Short -term toxicity
Short-term ecotoxicity data for freshwater at three trophic levels are available. The acute toxicity test showed that Daphnia is the most sensitive species with a EC50 of 55 mg/L.
The LC50 (96 h) to fish was indeed determined to be above the limit dose of 100 mg/L.
In a growth inibition test conducted with the green algae Desmodesmus s. an EC50 (72 h) of 106 mg/L and a NOEC of 10.2 mg/L were derived.
Long-term toxicity
A NOEC (21 d) of 2.7 mg/L was derived in a reproduction test conducted with Daphnia magna.
A range finding early life stage test was conducted to assess the effects of DHDPS on the most critical and sensitive life-stages of a freshwater fish zebrafish (Danio rerio) and to target test concentrations for a definitive extended one generation reproduction test.
A NOEC for survival of ≥ 10 mg/L was derived. For growth impairment the NOEC was ≥ 10 mg/L
Recent published screening studies with zebrafish (Naderi et al., 2014 and Ji et al., 2013 - see section 6.6 of substance dossier) have investigated potential adverse effects of 4,4'-sulphonydiphenol on the endocrine system in fish. A final assessment in the technical dossier is pending but will be completedin the course of the substance evaluation (REACH) process currently carried out by MSCA Belgium.
Activated Sludge
The EC10 of the test substance to activated sludge was tested to be 200 mg/L.
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