Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 905-806-4
CAS number: -
- All rats exposed to 0 (air) and 9.2 mg MDI/m3 tolerated the whole-body
exposure without specific signs whilst the 118 and 110 mg MDI/m3-exposed
rats experienced labored and irregular breathing patterns, bradypnea and
a serous nasal discharge. Mortality did not occur in any group. Apart
from the 'irregular breathing pattern' both the incidence and intensity
of clinical findings were almost identical in whole-body and nose-only
exposed rats. The signs observed were related to respiratory tract
- Comparisons of control and MDI-exposed rats did not reveal any
statistically significant effect on body weights, though there was a
tendency of slightly decreased body weight gains in nose-only exposed
- Statistical analysis of measurements of rectal temperatures revealed a
significant hypothermia in the nose-only exposed rats.
- in nose-only exposed rats, lung weights were increased to a greater
extent than in the in whole-body exposed rats. These findings are taken
as indirect evidence that the nose-only mode of exposure provides a more
rigorous means the expose rats to MDI. In whole-body exposed rats
measures were taken to prevent their huddling together or burying their
noses into the fur of neighboring rats in order to minimize their
exposure to irritant particulates. Nonetheless, the irritant-related,
reflexively induced hypothermia, associated with elevated lung weights ,
was only discernible in nose-only exposed rats.
- At no time point was there evidence of any effect on the frequency of
mast cells. The frequency of mast cells was low enough not to interfere
with the outcome of test. Rats treated with the positive control
substances displayed increased MN-PCE on sampling days 1 and 2, but not
on day 7. At no time point there was any evidence of an effect on the
frequency of MN-PCE in MDI-exposed animals. -No differences in outcome
existed following staining with the DANN-specific Acridine -Orange or
Wright-Giemsa. These results indicate that, under the experimental
conditions used, aerosolized MDI did not induce cytogenetic damage in
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again