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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
The study did not meet current requirements for repeated dermal toxicity testing, particularly in respect of the number and duration of exposures.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane
EC Number:
219-784-2
EC Name:
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane
Cas Number:
2530-83-8
Molecular formula:
C9H20O5Si
IUPAC Name:
trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane
Details on test material:
3-Glycidoxypropyltrimethoxysilane (TMSPGE, CAS No.
2530-83-8)

Test animals

Species:
rabbit
Strain:
other: other
Sex:
male

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
Approximately 1.25 hours/day
Frequency of treatment:
Two days (W, F) for the first week, three days (M, W, F) for the second week, and two days (M, W) for the third week for a total of 7 applications over 17 days
Doses / concentrations
Dose / conc.:
1 other: ml/kg
Control animals:
yes
Details on study design:
Post-exposure period: Not applicable.

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
> 1 other: ml/kg bw
Based on:
test mat.
Sex:
male
Basis for effect level:
other: No adverse effects observed.

Target system / organ toxicity

Critical effects observed:
no

Any other information on results incl. tables

There was no mortality or remarkable differences in body
weight or absolute/relative liver or kidney weights. 
Abnormal skin responses (desquamation, and fissures) were
noted on the test substance-treated rabbits.  No abnormal
skin responses were noted on the control animals.

Applicant's summary and conclusion

Conclusions:
The no-observed-effect-level (NOEL) for systemic effects was
determined to be greater than 1.0 mL/kg/application of the
test substance to rabbits under the conditions employed in
this study.