Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient details available to make a reliability assessment, reference could not be made available
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Influence of benzoic acid and benzoates on digestion and health.
Author:
Wiley HM, Bigelow WD
Year:
1908
Bibliographic source:
Bulletin 84, Part IV. Bureau of Chemistry, US Department of Agriculture

Materials and methods

Principles of method if other than guideline:
Method not determined: reference not located

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium benzoate
EC Number:
208-534-8
EC Name:
Sodium benzoate
Cas Number:
532-32-1
Molecular formula:
C7H6O2.Na
IUPAC Name:
sodium benzoate
Constituent 2
Reference substance name:
Benzoic acid, sodium salt
IUPAC Name:
Benzoic acid, sodium salt
Details on test material:
No data given

Method

Type of population:
general
Ethical approval:
confirmed and informed consent free of coercion received
Details on study design:
In a study with volunteers given 1000, 1500, 2000, or 2500 mg/day for 5 days each.

Results and discussion

Results:
At dose 1000, 1500, 2000, or 2500 mg/day, marked symptoms, signs of discomfort, and malaise (nausea, headache, weakness, burning and irritation of oesophagus) were reported.

Applicant's summary and conclusion