Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-534-8 | CAS number: 532-32-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Fish (acute): In the key study (Geiger, 1985) with Pimephales promelas the LC50 (96 h) was 484 mg/L based on measured concentrations under flow through conditions.
Fish (long-term): A long term study with Danio rerio in freshwater (Tsay, 2007) was available which was key study. This study showed that the NOEC is 10 mg/L.
Daphnia (acute): In the key study (Ewell, 1986) with daphnia magna the LC50 (96 h) was >100 mg/L based on nominal concentrations.
Daphnia (long-term): A long term study is waived based upon REACH Annex IX Section 9.1 column 2 on grounds that there is no need to further investigate the effects on aquatic organisms.
Algae: In the key study (Migchielsen, 2010) with Pseudokirchnerella subcapitata the EC50 (72 h) was >30.5 mg/L, EC10 (72h) was 6.5 mg/L and NOEC (72h) was 0.09 mg/L, based on measured concentrations.
Micro-organisms: In the key study with Achromobacter sp. (Nikkilä, 1955) the NOEC (168h) was >100 mg/L.
The algae study is based on measured concentrations and will be taken as starting point for the calculations of the PNECs for the aquatic compartment. The LC50 for fish is based upon measured concentrations and EC50 for daphnia is based on nominal concentrations. Based on the presence of a supporting static study in fish which showed a nominal LC50 of >100 mg/L (Ewell, 1986), it is expected that the concentrations in the key studies with fish and daphnia represent actual concentrations to sufficient extent. This allows the conclusion that the EC50 and EC10 of the algae study represent the worst case levels.
The reported NOEC for this study based upon time weighted average (TWA) concentrations do not accurately represent the intrinsic toxicity of the substance, which due to the issues with the lack of analytical detection of the test substance, the TWA concentrations that must be used resulted in a huge spacing factor between the LOEC and NOEC. EC10 better represent the potential toxicity of the substance as these are conservative estimates that biologically significant adverse effects are being demonstrated in the test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
