Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No detail about the method and the results
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
cancerogene alkylierende substanzen. III Alkyl-halogenide, -sulfate, -sulfonate und ringgespannte Heterocyclen
Author:
Druckrey H, Kruse H, Preussmann R, Ivankovic S,
Year:
1970
Bibliographic source:
Z. Krebsforsch. 74: 241-270

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No data a bout the method
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl sulphate
EC Number:
200-589-6
EC Name:
Diethyl sulphate
Cas Number:
64-67-5
Molecular formula:
C4H10O4S
IUPAC Name:
diethyl sulfate
Details on test material:
Purification: distillation in vacuum.
Supplier: Merck

Test animals

Species:
rat
Strain:
other: BD
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
arachis oil
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
350 mg/kg bw
Based on:
not specified

Any other information on results incl. tables

Death occured between 10 and 20 hours.

Lung oedema and hemorrhage of the intestin mucous membrane were observed upon necropsy.

Applicant's summary and conclusion

Conclusions:
The LD50 after sub-cutaneous injection is 350 mg/kg.
Executive summary:

An acute study was performed on rat with DES administrered by sc injections. In these conditions, the LC50 is 350 mg/kg.