Registration Dossier
Registration Dossier
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EC number: 283-294-5 | CAS number: 84604-16-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Saccharomyces cerevisiae, Saccharomycelaceae.
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- other: Review
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Guideline:
- other: Not applicable
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
Test material
- Reference substance name:
- Saccharomyces cerevisiae, ext.
- EC Number:
- 283-294-5
- EC Name:
- Saccharomyces cerevisiae, ext.
- Cas Number:
- 84604-16-0
- Molecular formula:
- Not applicable as the substance is an UVCB
- IUPAC Name:
- Yeast extract, Saccharomyces cerevisiae
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name of test material (as cited in study report): Yeast extract (SPRINGER 0251 / 0-MG-L)
- Substance type: Powder
- Physical state: light brown powder
- Analytical purity: Not indicated by the sponsor; treated as 100% pure
- Lot/batch No.: 071403960
- Expiration date of the lot/batch: 31 August 2017
- Stability under storage conditions: stable
- Storage condition of test material: At room temperature
- Solubility in water: very soluble (> 10000 mg/L) at 50°C and pH 5 to 5.5
Constituent 1
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- other: Not applicable
- Effect level:
- 0 other: Not applicable
- Based on:
- not specified
- Remarks on result:
- other: Review does not refer to the quantities.
Applicant's summary and conclusion
- Conclusions:
- Particles with an aerodynamic diameter > 10 µm are very unlikely to reach the gas-exchange region of the lung.
- Executive summary:
In occupational hygiene, particle size is usually described in terms of the aerodynamic diameter, which is a measure of the particle’s aerodynamic properties. Whether or not an airborne particle is inhaled depends on its aerodynamic diameter, the velocity of the surrounding air, and the persons’ breathing rate. How particles then proceed through the respiratory tract to the different regions of the lungs, and where they are likely to deposit, depend on the particle aerodynamic diameter, the airway dimensions and the breathing pattern.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
