Registration Dossier
Registration Dossier
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EC number: 283-294-5 | CAS number: 84604-16-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Saccharomyces cerevisiae, Saccharomycelaceae.
Endpoint summary
Administrative data
Description of key information
Additional information
Only an acute toxicity study with algae is available in which the yeast extract did not show any toxicity. Moreover, acute toxicity to fish and to aquatic invertebrates from S. cerevisiae Lysate dossier are available and show no toxicity. According to the read-across assessment, no toxicity of S. cerevisiae extract is expected in the aquatic compartment. Yeast, yeast extracts and yeast cell wall fractions have widely been fed to poultry, cattle and other livestock. In addition, many animals in ecotoxicity studies are fed or supplemented with yeast or yeast extracts. Yeast S. cerevisiae is one of the most widely used microorganisms as a DFM (Direct-Fed Microbials) in livestock operations. Finally, the The OECD guidelines for the testing of chemicals (OECD series on testing and assessment Number 55/ ENV/JM/MONO(2006)22) refer to the feeding of the aquacultures with yeast, following protocols for sediment toxicity and bioaccumulation test, such as US EPA (report 600/R-99/064 of March 2000).
To conlude, testing to evaluate long-term toxicity to aquatic invertebrates is not considered scientifically necessary and no toxicity of S. cerevisiae to aquatic compartments is expected .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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