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EC number: 266-929-0 | CAS number: 67701-05-7 This substance is identified by SDA Substance Name: C8-C18 and C18 unsaturated alkyl carboxylic acid and SDA Reporting Number: 01-005-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOELR (21d) >= 1.3 mg/L (measured, TWA); RA from decanoic acid (CAS 334-48-5)
Key value for chemical safety assessment
Additional information
For the members of the fatty acid category four chronic tests are available conducted with pure homologues of different chain lengths. The tested homologues were: decanoic acid (C10 - CAS 334-48-5), lauric acid (C12 - CAS 143-07-7), myristic acid (C14 - CAS 544-63-5) and palmitic acid (C16 - CAS 57-10-3). The linked studies were used in a weight of evidence approach for the evaluation of effects of the mixture on aquatic invertebrates.
For the evaluation of chronic effects of palmitic acid (C16: CAS 57 -11 -4) on aquatic invertebrates, daphnids were tested in a limit-test over a period of 21 days (NITE, 2008). The semi-static experiment was conducted according to OECD 211 in compliance with GLP-requirements. The used test concentration of 0.51 mg/L (nominal) corresponding to a mean measured value (time weighted mean) of 0.22 mg/L was above the reported water solubility limit. No effects could be observed on daphnids at this test concentration and thus the NOEC is reported to be 0.22 mg/L. As the low NOEC given in the study is only due to the low water solubility of the test substance the value was not used for PNEC-calculation of the considered mixture.
A study on the long-term toxicity of lauric acid (CAS 143 -07 -7) to aquatic invertebrates is available. This GLP study (Ministry of the Environment of Japan, 2001) was conducted according to OECD 211 and resulted in a NOEC (21 d) of 0.47 mg/L for Daphnia magna. Since severe deficiencies such as an invalid solvent control, instable test substance concentration, no defined dose-response curve and unknown fate of the test substance had been stated, the study was considered to be disregarded.
Furthermore a study on the long-term toxicity of myristic acid (C14: CAS 544 -63 -8) to aquatic invertebrates is available. The test was conducted according to OECD 211 in compliance with GLP over 21 days (NITE, 2003c). Due to the low water solubility, a solvent was used to presolve the test material. The study resulted in a measured NOEC of 0.31 mg/L. The reliability of the study results regarding the measured concentrations compared to the limit of water solubility are under discussion and therefore not taken into account for assessment.
In order to overcome methodological deficiencies in the studies, a test programme was setup in cooperation with the Fraunhofer Institute IME (FhG) in Schmallenberg/Germany. In the frame of this programme a new OECD 211 study with decanoic acid (CAS 334 -48 -5) was performed. The study was set up as limit test, in which the test item was prepared as WAF with a nominal loading of 5 mg/L and the medium was replaced daily. Samples were taken for chemical analysis from fresh and aged media during three representative 24 hours exposure periods per week. No immobilisation of daphnia occurred throughout the test, neither the mean cumulative offspring was affected. Based on the measured time weighted average concentration (TWA), a NOELR >= 1.3 mg/L has been determined (corresponding to the nominal load of 5 mg/L).
The result retrieved from the study with decanoic acid is currently used as read across to chronic daphnia toxicity of C8 –C18 fatty acids (CAS 67701-05-7). A detailed justification for the grouping of chemicals and read-across is provided in section 13 of the technical dossier.
Within the above mentioned test programme a new OECD 211 chronic toxicity study with lauric acid is in progress in order to overcome methodological deficiencies due to rapid decay of the test substance and to revise the hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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