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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption, other
Remarks:
in silico
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Study period:
October 11, 2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
See the attached justification.

Data source

Referenceopen allclose all

Reference Type:
other: software
Title:
Unnamed
Year:
2011
Reference Type:
other company data
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Guideline:
other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
Principles of method if other than guideline:
See the justification for type of information.

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
EC Number:
222-020-0
EC Name:
Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
Cas Number:
3319-31-1
Molecular formula:
C33H54O6
IUPAC Name:
tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Results and discussion

Percutaneous absorption
Time point:
4 h
Dose:
Deposition dose: 50000 mg
Parameter:
rate
Remarks:
absorbed
Absorption:
<= 0 mg cm-2 h-1

Any other information on results incl. tables

Substance

EC name: tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

CAS number: 3319-31-1

Molecular weight: 546.78

Temperature: 25 °C

Vapour Pressure: 6.8E-08 Pa

Water solubility: 3.06E-03 mg/L

Log Kow (skin, pH= 5.5): 8.0

Density: 988.5 mg/cm3

 

Scenario parameters

Instantaneous deposition

·        Deposition dose: 50000 mg (max. capacity of skin surface, equal to 25x affected skin)

·        Affected skin area: 2000 cm2 (hands and forearms surface)

 

Timing parameters

·        Start deposition: 0 hr

·        End time observation: 4 hr

 

Report parameters

·        Calculation intervals/hours: 10000 hr

·        Report intervals/hours: 1 hr

 

RESULTS

Deposition: Instantaneous

Tot. Deposition: 50000 mg

 

Fraction absorbed: 0.0%

Amount absorbed: 8.27E-03 mg

Lag time stratum corneum: 117.4 min.

 

Max. derm. abs.: 1E-06 mg/cm2/hr

Max. derm. abs. for 2000 cm2 in 1 hour (from liquid): 2.07E-03 mg

 

Dermal/Respiratory uptake ratio (from airborne vapour): R= 0.858

 

R= RX/X

 RX: total dermal absorption by dermal exposure to airborne vapour

X:  total inhalation absorption from airborne vapour

 

Assuming that Fully Respiratory Protection provides 100% efficiency:

Protection from respirator= 100*X/(RX+X)= 100/(R+1)= 100/1.858= 53.8% protection against overexposure to the substance in the form of vapour due to dermal vapour absorption over whole body surface.

Applicant's summary and conclusion

Conclusions:
The dermal absorption of the test material leads to the following results, obtained using the SkinPerm v1.03 model according to the input data:

Fraction absorbed: 0.0%
Amount absorbed: 8.27E-03 mg
Lag time stratum corneum: 117.4 min.

Max. derm. abs.: 1E-06 mg/cm2/hr
Max. derm. abs. for 2000 cm2 in 1 hour (from liquid): 2.07E-03 mg

Dermal/Respiratory uptake ratio (from airborne vapour): R= 0.858
Executive summary:

In-silico evaluation of dermal absorption indicates that after 4 hours the deposited substance is not absorbed within viable epidermis and therefore can not enter in systemic circulation.