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Ecotoxicological information

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Acute immobilisation in Daphnia has been investigated in a 48 hour test according to OECD test methods and using dissolution/dispersion agents to increase concentration of the substance in the test medium. The EC50 (48h) was determined to be >180 mg/L and the NOEC was 180 mg/L, the highest concentration investigated.

Algal growth inhibition has been investigated in a 72 hour test according to OECD test methods and using dissolution/dispersion agents to increase concentration of the substance in the test medium. The EC50 (72h) was determined to be >100 mg/L and the NOEC was 100 mg/L, the highest concentration examined.

Acute toxicity to fish has been investigated in a 96 hour test according to OECD test methods and using dissolution/dispersion agents to increase concentration of the substance in the test medium. The LC50 (96h) was determined to be >100 mg/L.

Chronic toxicity to Daphnia has been investigated in a 21 -day reproduction test 48 hour test according to OECD test methods and using dissolution/dispersion agents to increase concentration of the substance in the test medium. The NOEC (21 -day, reproduction) was 55.6 mg/L; LOEC (21 -day, reproduction) was >100 mg/L and the EC50 (21 -day, reproduction) was 89.1 mg/L. A second chronic Daphnia study has been conducted according to ASTM/EPA test methods, again using dissolution/dispersion agents to increase concentration of the substance in the test medium. The following values were calculated: NOEC (21 -day, reproduction): 0.082 mg/L; LOEC (21 -day, reproduction): >0.082 mg/L; EC50 (21 -day, reproduction): >0.082 mg/L. These lower values compared with the first study reflect the achieved concentrations of the substance in the test media, this influenced by the agents used to achieve dissolution/dispersion.

Toxicity to fish has been investigated in 14 day test according to OECD test methods using dissolution/dispersion agents to increase concentration of the substance in the test medium. The 14 day NOEC was determined to be 75.0 mg/L. It is recognised that the duration of the OECD TG 204 test is shorter than that currently accepted for investigating long-term toxicity in fish. Waiving of repeat or additional testing is proposed based both on the lack of effects seen in the 14 -day fish study and chronic Daphnia reproduction studies together with considerations regarding adequate justification for the use of vertebrate species for experimental purposes.