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EC number: 203-713-7 | CAS number: 109-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficiently well reported to regard as reliable contributor to data for this end point
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The effects on the rat of single inhalation exposures to ethylene glycol monoalkyl ethers, in particular ethylene glycol monomethyl ether,
- Author:
- Samuels DM, Doe JE, Tinston DJ
- Year:
- 1 984
- Bibliographic source:
- Arch Toxicol, 7, p167-70
- Reference Type:
- publication
- Title:
- Further studies on the toxicology of the glycol ethers with emphasis on rapid screening and hazard assessment.
- Author:
- Doe JE
- Year:
- 1 884
- Bibliographic source:
- Env Hlth Persp, 57, 199-206
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The purpose of the study was to assess testes effects following acute exposure. However, the methodology used does provide acute lethality information.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methoxyethanol
- EC Number:
- 203-713-7
- EC Name:
- 2-methoxyethanol
- Cas Number:
- 109-86-4
- Molecular formula:
- C3H8O2
- IUPAC Name:
- 2-methoxyethanol
- Details on test material:
- Supplier: Merck
Purity: 99.5%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park (Alpk) albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 8 week old pathogen free animals used. Animals acclimatized to whole body test chambers for 24 hours before transferring to holding cages for 13 days observation after exposure.
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Concentrations monitored using an infra-red analyzer.
- Duration of exposure:
- ca. 4
- Concentrations:
- 150, 300, 625, 1250, 2500, 5000ppm. Top dose corresponded to saturated vapour pressure of 15.8mg/l.
- No. of animals per sex per dose:
- 20 plus 40 control animals.
- Control animals:
- yes
- Details on study design:
- Body weights recorded on day -1, 6 and 13. Animals sacrificed on day 13 and sex organs examined
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- > 15.8 mg/L air
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- other: NOAEC
- Effect level:
- ca. 0.95 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- There was no record of any deaths at any exposure concentration.
- Gross pathology:
- Dose related decrease in testes weight from 1250ppm upwards.
- Other findings:
- Testes weights were not affected at 650ppm but there was evidence of sperm damage (minimal degenerative changes), disordered spermatogenesis, tubular atrophy). The NOAEL from the study was 300ppm (0.95mg/l).
Any other information on results incl. tables
The results do not provide a true LC50 and as such are only of partial use for classification and labeling purposes, but they can be used to derive a NOAEL for risk assessment purposes with appropriate safety factors.
In the second study, disordered spermatogenesis was seen in exposed animals (both dose levels) which persisted until the end of the observation period on day 19.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- It can be concluded that the LC50 is greater than 5000ppm (15.8mg/l)
- Executive summary:
In a study designed to assess testes effects following acute exposure, male rats were exposed to a number of concentrations of methoxyethanol in the range 150ppm up to saturated vapour pressure for a period of 4 hours. No deaths were observed at any concentration. However, the study did note adverse effects on the testes of animals exposed to 625ppm and above of methoxyethanol, producing a NOAEC of 300ppm. The study did not provide a true LC50 and as such the results are only of partial use for classification and labeling purposes, but they can be used to derive a NOAEL for risk assessment purposes with appropriate safety factors. It can also be concluded that the LC50 is greater than 5000ppm (15.8mg/l)
Results synopsis
LC0>15.8mg/l (4hrs exposure)
NOAEC=0.95mg/l (4hrs exposure, testes effects)
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