2-ethoxyethanol

Repeated dose toxicity: other routes

Administrative data

Endpoint:

short-term repeated dose toxicity: other route

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable publication

Data source

Reference

Reference Type:

publication

Title:

german [Zur Toxikologie des Äthylenglykol-Monoäthyläthers]; english translation [On the Toxicology of Ethyleneglycol-monoethylether]

Author:

Stenger EG, Aeppli L, Müller D, Peheim E, Thomann P

Year:

1971

Bibliographic source:

Arzneimittel-Forschung (Drug Research) 6: 880-885

Materials and methods

Principles of method if other than guideline:

Method: other: Subacute toxicity (subcutaneous and intravenous)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxyethanol

EC Number:

203-804-1

EC Name:

2-ethoxyethanol

Cas Number:

110-80-5

Molecular formula:

C4H10O2

IUPAC Name:

2-ethoxyethan-1-ol

Details on test material:

Name of the test substance as stated in the publication: "Äthylenglykol-Monoäthyläther";
purity: "zur Synthese";
purchased from Merck

Test animals

Species:

other: rat and dog

Strain:

other: Wistar "CF-Mehrzweck", Beagle

Sex:

male/female

Administration / exposure

Route of administration:

other: subcutaneous (rats), intravenous (dogs)

Duration of treatment / exposure:

4 weeks rats;
22 days dogs

Frequency of treatment:

daily

Doses / concentrations

Remarks:

Doses / Concentrations:
subcutaneous rats: 5 mL/kg in back (100, 200, 400, 800 µL/kg/day)
intravenous dogs: 0.1, 0.5 mL/kg in extremities

No. of animals per sex per dose:

Rats: 5
Dogs: 2

Control animals:

other: yes, adminstration of same volume of physiological NaCl-solution at the corresponding application route

Results and discussion

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

Results for rats (4 weeks, sc.):

At doses of 100 and 200 µL/kg/day the injection sites showed slight chronic inflammation, but these were also observed in the corresponding control group (subcutaneous injection of physiological saline). At 400 µL/kg additionally to the slight chronic inflammation at the injection sites the 5 male rats showed testicular damage. In all animals of this dosage group changes in the liver and kidneys was observed. The observartions in the 800 µL/kg/day dose-group were the same as in the lower dose group, but more severe.

Results for dogs (22 days, iv.):

In no dose group histological changes of the inner organs were observed. At 100 µL/kg/day slight inflammation was observed at the injection sites, in two cases there was thrombosis of a vein. At 500 µL/kg/day all animals showed a predominant thrombophlebitis with severe inflammation.