Registration Dossier
Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication and testing conducted according to a standardized procedure
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimental study of cutaneous tolerance to glycol ethers
- Author:
- Zissu, D.
- Year:
- 1 995
- Bibliographic source:
- Contact Dermatitis 32, 74-77
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive annex: 92/69/EEC: July 1992
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethan-1-ol
- Details on test material:
- Name of the test substance as stated in the publication: 2-ethoxyethanol;
purchased from: Merck;
purity: > 99 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: animal served as its own control
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- < 0.5
- Max. score:
- 8
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Macroscopic investigation of cutaneous irritation according to the method of the official Journal of the European Communities showed that the test substance 2 -ethoxyethanol was non-irritant.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- The skin irritating potential of the test substance 2-ethoxyethanol was evaluated according to the Directive annex: 92/69/EEC: July 1992 on the skin of New Zealand albino rabbits. The test substance was applied undiluted occlusively for 4 hours. The result showed that the test substance was not irritating.
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