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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The Toxicological Basis of Threshold Limit Values: 5. The Experimental Inhalation of Vapor Mixtures by Rats, with Notes upon the Relationship between Single Dose Inhalation and Single Dose Oral Data
Author:
Pozzani U.C., M.S., Weil C.S., M.A., Carpenter C.P., Ph.D.
Year:
1959
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 20, 364-369
Reference Type:
publication
Title:
Use of Moving Averages and Interpolation to Estimate Median-Effective Dose.
Author:
Thompson, W.R.
Year:
1947
Bibliographic source:
Bact. Rev. 11: 115
Reference Type:
publication
Title:
The Assay of Acute Vapor Toxicity, and the Grading and Interpretation of Results on 96 Chemical Compounds.
Author:
Carpenter C.P., Smyth H.F., Jr., and Pozzani, Urbano C.
Year:
1949
Bibliographic source:
J. Ind. Hyg. and Toxicol. 31: 343

Materials and methods

Principles of method if other than guideline:
Acute inhalation toxicity
GLP compliance:
no
Test type:
other: acute inhalation toxicity

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethoxyethanol
EC Number:
203-804-1
EC Name:
2-ethoxyethanol
Cas Number:
110-80-5
Molecular formula:
C4H10O2
IUPAC Name:
2-ethoxyethan-1-ol
Details on test material:
Test substance as stated in publication: "CELLOSOLVE"
Purity: commercial grade

Test animals

Species:
rat
Strain:
other: Carworth Farms-Nelson
Sex:
female

Administration / exposure

Route of administration:
inhalation: vapour
Duration of exposure:
8 h
Concentrations:
4.01 - 13.5 mg/l
No. of animals per sex per dose:
6

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LC50
Effect level:
7.36 mg/L air
Exp. duration:
8 h

Applicant's summary and conclusion

Conclusions:
6 female rats were exposed to different vapour concentrations (4.01 to 13.5 mg/L) of the test substance 2-ethoxyethanol for a single 8-hour period. The LC50 was determined to be 7.36 mg/L, at this concentration 50 % of the exposed animals died.