Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
biological effects monitoring
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable procedure and publication

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Cytotoxicity of 109 Chemicals to Goldfish GFS Cells and Relationships with 1-Octanol/Water Partition Coefficients
Author:
Saito, H. et al.
Year:
1993
Bibliographic source:
Chemosphere 26(5), 1015-1028
Reference Type:
publication
Title:
Quantitative Structure-Activity Relationships in Fish Toxicity Studies
Author:
Koenemann, H.
Year:
1981
Bibliographic source:
Toxicology, 19, 209-221

Materials and methods

Principles of method if other than guideline:
Neutral red (NR) assay
GLP compliance:
not specified
Type of study / information:
Midpoint cytotoxicity of 2-ethoxyethanol to goldfish scale GFS cells compared with the fish acute toxicities and partition coefficient (log Pow).

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethoxyethanol
EC Number:
203-804-1
EC Name:
2-ethoxyethanol
Cas Number:
110-80-5
Molecular formula:
C4H10O2
IUPAC Name:
2-ethoxyethan-1-ol
Details on test material:
Name of the test substance as stated in the publication: 2-ethoxyethanol
Purchased from: Tokyo Kasei Kogyo Co., Tokyo, Japan;
Purity: " reagent-grade"

Results and discussion

Any other information on results incl. tables

Data of log Pow, NR50 for GFS cells and LC50 for guppy: (log Pow and LC50 values from Koenemann, H. (1981))

  Log Pow   Log 1/NR50 (mmol/L)  Log 1/LC50 (mmol/L), guppy
 2 -ethoxyethanol  -0.21  -2.54  -2.26

Applicant's summary and conclusion

Conclusions:
The 24-hr NR50 values (in vitro) for the cytotoxicity of the test compound 2-ethoxyethanol to GFS cells, together with their log Pow and LC50 data (in vivo) for guppy gave good correlations.