Ethylene carbonate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions (partly limited documentation; post exposure observation period 7 days; low number of rats)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1960

Report date:

1960

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

Annex of the Guideline 403

Deviations:

yes

Remarks:

see rationale for reliability

GLP compliance:

no

Test type:

other: inhalation hazard test

Test material

Test material information

Constituent 1

Reference substance name:

Ethylene carbonate

EC Number:

202-510-0

EC Name:

Ethylene carbonate

Cas Number:

96-49-1

Molecular formula:

C3H4O3

IUPAC Name:

1,3-dioxolan-2-one

Test material form:

solid: crystalline

Details on test material:

- Name of test material (as cited in study report): Ethylene carbonate
- Purity: > 99%
- Physical state: fine crystals

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

No details

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: air

Details on inhalation exposure:

Rats exposed for 8 h to a vapour saturated atmosphere.
Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder. The liquid had a temperature of 50°C; air pressure was 754 mm Hg. Temperature in the exposure chamber presumably 26°C (not clearly stated)

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Concentrations:

Saturated vapour. The authors calculated a concentration of 730 mg/m³ (1.17 g substance loss).

No. of animals per sex per dose:

3 males and 3 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: observations performed (no details), body weight determined at day 0 and 4
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC0

Effect level:

730 mg/m³ air

Exp. duration:

8 h

Remarks on result:

other: saturated vapour

Mortality:

No mortality

Clinical signs:

other: No clinical signs

Body weight:

No effects on body weight (measured day 0 and day 4)

Gross pathology:

No effects detected at necropsy

Other findings:

No

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

No mortality in male and female rats exposed to saturated vapour for 8 h.

Executive summary:

The study is comparable to the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions (partly limited documentation; post exposure observation period 7 days; low number of rats).

Three male and 3 female rats were exposed for 8 h to saturated vapour. The authors calculated a concentration of 730 mg/m³. No clinical signs were observed and no mortality occurred during the 7 days of post exposure observation period. No effects were detected at necropsy.

Conclusion: No mortality in male and female rats exposed to saturated vapour for 8 h.