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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
cytotoxicity
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1997

Materials and methods

Principles of method if other than guideline:
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazorium bromide (MTT) assay
GLP compliance:
not specified
Type of method:
in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
Dodecyl methacrylate
EC Number:
205-570-6
EC Name:
Dodecyl methacrylate
Cas Number:
142-90-5
Molecular formula:
C16H30O2
IUPAC Name:
dodecyl 2-methylprop-2-enoate
Details on test material:
2-Propenoic acid, 2-methyl-, dodecyl ester purity not specified, but commercial grade assumed.

Results and discussion

Details on results:
The Cytotoxic effect of Dodecyl methacrylate on the relative cell viability of HeLa S3 cells was IC50: 0.67 mmol/L (50 % depression of MTT-formazan production).

Applicant's summary and conclusion

Conclusions:
The Cytotoxic effect of Dodecyl methacrylate on the relative cell viability of HeLa S3 cells was IC50: 0.67 mmol/L (50 % depression of MTT-formazan production).