Registration Dossier
Registration Dossier
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EC number: 292-122-8 | CAS number: 90552-02-6
Endpoint summary
Administrative data
Description of key information
The acute toxicity of the long-chain alkyl methacrylate esters (C12 – C22) can be considered as very low by the oral and dermal route. The inhalation route is not of relevance due to the very low vapour pressure of the substances.
Key value for chemical safety assessment
Additional information
Acute oral toxicity studies with LD50 values above 5000 mg/kg indicate a very low toxic potential of the long-chain alkyl methacrylate esters (C12 – C22).
There are only few data on dermal toxicity testing of the esters in rabbits which are of limited reliability. They are indicating low dermal toxicity, LD50 values above 3000 mg/kg.With regard to the low acute oral toxicity and the characteristics of skin penetration and metabolism in the skin, the acute dermal toxicity can be considered as low.
This skin absorption study indicates that the total amount of the ester dodecyl methacrylate that was absorbed during the time of exposure was 0.7 % (rat epidermis) and 0.26 % (rat whole skin) over 24 hours, respectively.
Hence, bearing in mind the already low acute oral toxicity, toxic effects via the dermal route are unlikely.
Taken as a whole there are sufficient data available for the long-chain alkyl methacrylate esters for assessment purposes so for the sake of animal welfare it is not proposed to repeat this study.
The inhalation route is not of relevance due to the very low vapour pressure of the substances.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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