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Diss Factsheets
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EC number: 210-483-1 | CAS number: 616-45-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EEC directive 79/831 EEC, Annex V, C2
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test medium of the higest test concentration (nominal 500 mg/L) was used as a stock solution. This test medium was serially diluted with culture medium to obtain the desired test concentrations (31.25, 62.5, 125, 250, 500 mg/L). A control, containing culture medium only was tested in parallel. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: originally obtained from the Institute National de Recherche Chimique Appliquee, France and cultured in the laboratories of BASF since 1978.
- Age at study initiation (mean and range, SD): 2 - 24 hours - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 19 - 21 °C
- pH:
- 7.8 - 8.1
- Dissolved oxygen:
- 7.0 - 9.2 mg/L
- Nominal and measured concentrations:
- Nominal test concentrations (mg/L): 31.25, 62.5, 125, 250, 500 and control
- Details on test conditions:
- TEST SYSTEM
- Test vessel: flat bottom glass tubes
- Fill volume: 10 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to the test guideline DIN 38412, L 11
OTHER TEST CONDITIONS
- Photoperiod: 16:8 hours, diffuse light (ca. 5 µE/m²*s)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mobility after 0, 3, 6, 24, 48 h - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- 24 hour ECx values: EC0: 500 mg/L EC50: > 500 mg/L EC100: > 500 mg/L
- Reported statistics and error estimates:
- No statistical analysis of the data was performed. The EC0, the EC50 and the EC100 were determined directly from the raw data.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test revealed a no-effect concentration (EC0) of 500 mg/L, whereas an EC50 of >500 mg/L was determined.
- Executive summary:
An acute toxicity test with Daphnia magna was performed according to EEC directive 79/831 EEC, Annex V, C2. Thr following nominal test concentrations 31.25, 62.5, 125, 250, 500 mg/L and a control were investigated. As effect parameter the mobility after 0, 3, 6, 24, 48 h was measured. The test revealed a no-effect concentration (EC0) of 500 mg/L, whereas an EC50 of >500 mg/L was determined.
Reference
Description of key information
The key value for chemical safety assessment
was experimentally determined by BASF AG (1988). An acute toxicity test
with Daphnia magna was performed according to EEC directive 79/831 EEC,
Annex V, C2.
The test revealed a no-effect concentration (EC0) of 500 mg/L, whereas
an EC50 of >500 mg/L was determined.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 500 mg/L
Additional information
The acute toxicity of 2 -Pyrrolidone towards aquatic invertebrates was determined according to Directive 79/831/EEC, Annex V, C2 (1984) with Daphnia magna as test organism (BASF AG, 1988). In this static freshwater test, nominal substance concentrations of 0 (control), 31.25, 62.5, 125, 250, and 500 mg/L were tested. In the test vessels, 5 animals were exposed to 10 mL test medium for 48 hours, respectively. 4 replicates per test concentration were used. As final results, the EC0 (48 h) amounts to 500 mg/L while the EC50 (48 h) was determined to be > 500mg/L.
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