Registration Dossier
Registration Dossier
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EC number: 225-935-3 | CAS number: 5160-02-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
According to Annex IX of Regulation (EC) No 1907/2006 a study on bioaccumulation does not need to be conducted if the substance has a low potential for bioaccumulation (e.g. a log Kow < 3) and/or a potential to cross biological membranes. Metal laked pigments have a log Kow << 3 and therefore, significant accumulation in organisms is not to be expected.
The assumption is supported by three guideline studies. In the first study on CAS 5281 -04 -9, fish (Cyprinus carpio) were exposed to test substance concentrations of 0.3 mg/L and 0.03 mg/L respectively. The test was terminated after 6 weeks of exposure. At a substance concentrations of 0.3 mg/l a BCF of 0.7 - 1.8 was determined. At a concentration of 0.03 mg test substance/l a BCF < 6.9 was detected (JETOC, 1992).
The second guideline study on CAS 73612 -29 -0 could not properly be evaluated due to limited data. However, the results from this study did not reveal any potentital to bioaccumulate, either. In this test, fish (Cyprinus carpio) were exposed to test substance concentrations of 0.1 mg/l and 0.01 mg/l respectively. The test was terminated after 28 days of exposure. At a substance concentrations of 0.1 mg/l a BCF of <= 4.4 was determined. At a concentration of 0.01 mg test substance/l a BCF <= 0.44 was detected.
A third study on CAS 5160 -02 -1 revealed a BCF of 0.9 to 15 at test substance concentrations of 0.7 and 0.07 mg/L, respectively. In this test, Cyprinus carpio were exposed for 42 days.
For the detailed read across justification please refer to the annex attached to the CSR.
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