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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1973
Reference Type:
publication
Title:
Acute toxicologic evaluation of Santocure NS vulcanization accelerator
Author:
Randall, D.J. and Bannister, R.M.,
Year:
1990
Bibliographic source:
Acute Toxic. Data 1 (2), 104-105

Materials and methods

Principles of method if other than guideline:
A 25% suspension of Santocure NS vulcanization accelerator (N-tert-butylbenzothiazole-2-sulphenamide) in corn oil was administrated by gavage to 4 groups of 5 (mixed males and females) Sprague-Dawley albino rats at doses of 6310 or 7940 mg/kg bw. A 10 -day observation period followed administration.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-tert-butylbenzothiazole-2-sulphenamide
EC Number:
202-409-1
EC Name:
N-tert-butylbenzothiazole-2-sulphenamide
Cas Number:
95-31-8
Molecular formula:
C11H14N2S2
IUPAC Name:
N-(1,3-benzothiazol-2-ylsulfanyl)-2-methylpropan-2-amine
Details on test material:
Santocure NS vulcanization accelerator 97%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
6310, 7940 mg/kg bw
No. of animals per sex per dose:
5 per dose (mixed males and females)
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 6 310 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Clinical signs: reduced appetite and activity (three to five days in survivors), increased weakness, collapse, and death (in decedents).
Mortality:
6310 mg/kg bw: 0/3 males, 0/2 females, combined: 0/5
7940 mg/kg bw: 1/2 males, 2/3 females, combined: 3/5
time of mortality: 4 to 9 days
Clinical signs:
Reduced appetite and activity (three to five days in survivors), increased weakness, collapse, and death.
Gross pathology:
Decedents: Lung congestion, liver discoloration, acute gastrointestinal inflammation.
Surviors (10 days): Viscera appeared normal.

Any other information on results incl. tables

Mortality:

6310 mg/kg bw: 0/3 males, 0/2 females, combined: 0/5

7940 mg/kg bw: 1/2 males, 2/3 females, combined: 3/5

time of mortality: 4 to 9 days

Clinical signs: reduced appetite and activity (three to five days in survivors), increased weakness, collapse, and death

Gross autopsy decedents: Lung congestion, liver discoloration, acute gastrointestinal inflammation

Surviors (10 days) viscera appeared normal

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 > 6310 mg/kg bw (rats).
Executive summary:

A 25% suspension of Santocure NS vulcanization accelerator (N-tert-butylbenzothiazole-2-sulphenamide) in corn oil was administrated by gavage to 4 groups of 5 (mixed males and females) Sprague-Dawley albino rats at doses of 6310 or 7940 mg/kg bw. A 10 -day observation period followed administration. A LD50 > 6310 mg/kg bw (rats) was determined.