Titanium tetraisopropanolate

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Pre-dates GLP and guidelines, insufficient information on study methods and findings

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1960

Report date:

1960

Materials and methods

Test guideline

Guideline:

other: No test guideline referenced

Test material

Test material information

Constituent 1

Reference substance name:

Titanium tetraisopropanolate

EC Number:

208-909-6

EC Name:

Titanium tetraisopropanolate

Cas Number:

546-68-9

Molecular formula:

C12H28O4Ti

IUPAC Name:

titanium tetraisopropanolate

Details on test material:

Haskell batch number 2489

Test animals

Species:

rat

Strain:

other: ChR-CD

Sex:

male

Administration / exposure

Route of administration:

other: Ingestion

Details on oral exposure:

The animals were dosed 5 times a week for 2 weeks, receiving in total 10 doses of 2200 mg/kg (20% in peanut oil) each dose

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

2 weeks (10 doses)

Frequency of treatment:

daily 5/7 days for 2 weeks

Doses / concentrations

Remarks:

Doses / Concentrations:
2200 mg/kg
Basis:
actual ingested

No. of animals per sex per dose:

6

Examinations

Observations and examinations performed and frequency:

Clinical signs and bodyweights of the animals were measured but frequency was not reported.

At 4 hours after the 10th dose, 3/6 animals were killed, necropsied and tissues examined macroscopically. The remaining 3/6 animals were allowed a 10 day recovery period prior to sacrifice and necropsy examination.

Results and discussion

Results of examinations

Clinical signs:

effects observed, treatment-related

Description (incidence and severity):

slight stiffness in hind legs and irritability

Mortality:

mortality observed, treatment-related

Description (incidence):

slight stiffness in hind legs and irritability

Body weight and weight changes:

effects observed, treatment-related

Description (incidence and severity):

slowed rate of weight gain

Gross pathological findings:

no effects observed

Details on results:

Repeated high sub-lethal doses of 2200 mg/kg caused signs of mild cumulative toxicity from which the rats rapidly recovered when dosing ceased. Tissue changes were not observed grossly or microscopically in the 3 rats killed 4 hours after the 10th treatment or in the 3 killed 10 days later.
It is concluded that the test item has a low order of cumulative oral toxicity under the conditions described.

Target system / organ toxicity

Critical effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

Whilst the information supplied following 10 treatments of 2200 mg/kg is suggestive of a low order of repeat dose toxicity there is insufficient information on study methods and observations. There is no indication of which tissues were examined at necropsy or which tissues were processed microscopically for examination.