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EC number: 208-909-6 | CAS number: 546-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Pre-dates GLP and guidelines, insufficient information on study methods and findings
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
Test guideline
- Guideline:
- other: No test guideline referenced
Test material
- Reference substance name:
- Titanium tetraisopropanolate
- EC Number:
- 208-909-6
- EC Name:
- Titanium tetraisopropanolate
- Cas Number:
- 546-68-9
- Molecular formula:
- C12H28O4Ti
- IUPAC Name:
- titanium tetraisopropanolate
- Details on test material:
- Haskell batch number 2489
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
Administration / exposure
- Route of administration:
- other: Ingestion
- Details on oral exposure:
- The animals were dosed 5 times a week for 2 weeks, receiving in total 10 doses of 2200 mg/kg (20% in peanut oil) each dose
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 weeks (10 doses)
- Frequency of treatment:
- daily 5/7 days for 2 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2200 mg/kg
Basis:
actual ingested
- No. of animals per sex per dose:
- 6
Examinations
- Observations and examinations performed and frequency:
- Clinical signs and bodyweights of the animals were measured but frequency was not reported.
At 4 hours after the 10th dose, 3/6 animals were killed, necropsied and tissues examined macroscopically. The remaining 3/6 animals were allowed a 10 day recovery period prior to sacrifice and necropsy examination.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- slight stiffness in hind legs and irritability
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- slight stiffness in hind legs and irritability
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- slowed rate of weight gain
- Gross pathological findings:
- no effects observed
- Details on results:
- Repeated high sub-lethal doses of 2200 mg/kg caused signs of mild cumulative toxicity from which the rats rapidly recovered when dosing ceased. Tissue changes were not observed grossly or microscopically in the 3 rats killed 4 hours after the 10th treatment or in the 3 killed 10 days later.
It is concluded that the test item has a low order of cumulative oral toxicity under the conditions described.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Whilst the information supplied following 10 treatments of 2200 mg/kg is suggestive of a low order of repeat dose toxicity there is insufficient information on study methods and observations. There is no indication of which tissues were examined at necropsy or which tissues were processed microscopically for examination.
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