Registration Dossier

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Testing is not scientifically justified as this substance is hydrolytically unstable and the decomposition products possess low aquatic toxicity. The read-across result of the 16-h toxicity threshold of isopropyl alcohol (IPA) to Pseudomonas putida (cell multiplication); 1050 mg/l, based on the nominal concentrations, is used as key value in CSA. 

Key value for chemical safety assessment

EC50 for microorganisms:
1 050 mg/L

Additional information

As the target substance hydrolyses immediately (half-life < 3 minutes) the toxicity to microorganisms is related to this main organic degradation product (IPA) of the target substance.

According to the ECHA Guidance on information requirements and chemical safety assessment, in absence of activated respiration test, toxicity results to microbial bacteria can be used for evaluate the inhibitory effects of chemicals to STP micro-organisms. Therefore, the result of the P.putida cell multiplication inhibition test of the organic hydrolysing product (IPA) with Klimisch score 2 is used to calculate the PNEC STP.