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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Testing is not scientifically justified as this substance is hydrolytically unstable and the decomposition products have a low potential for aquatic bioaccumulation and a low potential to cross biological membranes. Acute toxicity (96-h LC50) of the main decomposition product (IPA) is used as a key value.

Key value for chemical safety assessment

LC50 for freshwater fish:
4 200 mg/L

Additional information

When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than isopropyl alcohol and hydrated titanium dioxide (key study on hydrolysis OECD 111). The organic decomposition product (IPA) is readily biodegradable having also a low log Kow value (0.05).

The CSA indicates that toxicity of this substance is similar to the main degradation product (IPA). Key studies (short-term toxicity to daphnia and algae, Klimisch score 1) conducted for this substance justify that this substance hydrolyses during toxicity testing and the aquatic toxicity is similar to the alcohol released in water. Therefore, and for reasons of animal welfare, a short-term toxicity study on fish is unjustified, and the key value for CSA is obtained from the lowest 96-h LC50 (Rasbora heteromorpha) read-across data of isopropyl alcohol (peer-reviewed secondary source Tooby & Hursey 1975).