Registration Dossier

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.59 mg/L
Assessment factor:
1 000
PNEC freshwater (intermittent releases):
5.9 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.059 mg/L
Assessment factor:
10 000

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
105 mg/L
Assessment factor:
10

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.482 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.048 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.112 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

The following reliable data is available for environmental classification of titanium tetraisopropanolate:

Acute Aquatic Toxicity:

Short-term toxicity to fish:

96-h LC50 (mortality) to Rasbora heteromorpha; 4200 mg/L based on nominal concentrations (read-across from IPA; Tooby & Hursey 1975)

Short term toxicity to invertebrates:

48-hour EC50 (immobilisation) to Daphnia magna; 590 mg IPA/l (95 % CI, 570 to 610 mg IPA/l) based on the measured (0-hour) concentrations. (OECD 202; Goodband 2010)

48-hour EC50 (immobilisation) to Daphnia magna; 700 mg/l (95% Cl, 680 to 720 mg /l based on the equivalent test item concentrations. (OECD 202; Goodband 2010)

Toxicity to algae:

The 72h-EC50 (growth rate) to Desmodesmus subspicatus; >820 mg /l based on measured IPA concentrations (OECD 201; Vryenhoef & Mullee 2010)

The 72h-NOEC (growth rate) to Desmodesmus subspicatus; 201 mg /l based on measured IPA concentrations (OECD 201; Vryenhoef & Mullee 2010)

The 72h-EC50 (growth rate) to Desmodesmus subspicatus; >960 mg /l based on equivalent test item concentrations (OECD 201; Vryenhoef & Mullee 2010)

The 72h-NOEC (growth rate) to Desmodesmus subspicatus; 237 mg /l based on equivalent test item concentrations (OECD 201; Vryenhoef & Mullee 2010)

Conclusion: No acute aquatic toxicity as the lowest of the available toxicity value is > 100 mg/l.  

Degradation:  

Abiotic degradation (hydrolysis): Hydrolytically unstable, Half-life less than 3 minutes (OECD 111)

Main organic decomposition product (IPA) is non-toxic to aquatic environment and readily biodegradable (> 70 % at 20-d biodegradation, Price et al. 1974) The aquatic toxicity values (EC50/LC50) of the main degradation product (IPA) based on the literature are:

Scenedesmus quadricauda, 1800 mg/l in freshwater

Daphnia magna, 6850 mg/l in freshwater

Daphnia magna, >10 000 mg/l in freshwater

Artemia salina, >10000 mg/l in artificial sea water

Pimephales promelas, 9640 mg/L in fresh water

Pimephales promelas,11130 mg/L in lake superior water

Rasbora heteromorpha, 4200 mg/L in fresh water

Conclusion: rapidly degradable.  

Bioaccumulation:

Log Kow for the main degradation product (IPA) is 0.05. Not possible to determine for the target substance because of rapid hydrolysis.  

Conclusion: No chronic aquatic toxicity as the lowest available toxicity value is > 100 mg/l, substance is rapidly degradable, and the degradation products have low potential for bioconcentration and bioaccumulation.  

Environmental classification:

In accordance with EC Regulation 1272/2008 (CLP):

Not classified as hazardous

In accordance with DSD (Directive 67/548/EEC):

Not classified as hazardous