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EC number: 500-040-3
CAS number: 25686-28-6
No long-term fish toxicity tests are available for the test substance. Due to the reactivity of the MDI substances with water and the extremely low water solubility it is considered appropriate to waive this study.
Due to the reactivity of the MDI substances with water, no fully adequate information from long-term aquatic fish toxicity studies of the MDI parent substances themselves is available. Also, these cannot be generated in a sound scientific manner. Any kind of media preparation for semi-static or flow-through exposures would involve hydrolysis, and thus the formation of degradation products. First and foremost, these are solid, inert and insoluble polyurea. These would be separated by centrifugation or filtration during WAF preparation and would therefore no longer be part of the final test medium. The same would apply to the evolving carbon dioxide, which would volatize from the testing medium. The only test compound that could potentially be remaining in the test solution would be the side-product MDA at a very low concentration. However, a long-term exposure to MDA would not occur under relevant environmental exposure scenarios, and the aquatic effects of MDA are known. The further common degradation product MDA has been adequately characterized with respect to its short- and long-term toxicity to aquatic organisms. The data generated confirms that representative MDI substances of the category do not cause adverse acute effects in fish at the loading limit concentration of 100 mg/L. Fish are not considered the most sensitive species. Hence, the entire category is considered not acute harmful towards this species. As fish are not considered to be the most sensitive species, there would be no information gain from a long-term aquatic study on the MDI category substances. In conclusion, there are no adequate chronic aquatic fish data on the MDI category substances (as such) available and cannot be meaningfully generated for the reasons mentioned. Additional testing is therefore not warranted.
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