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EC number: 253-733-5
CAS number: 37971-36-1
The skin sensitisation effect of tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarboxylate was examined in guinea pigs by a Guinea Pig Maximisation Test (GPMT) according to Magnusson and Kligman. The intradermal induction was done with 5% test item, followed by topical induction and challenge test, both with the undiluted (100%) test item (32.6 % Tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarboxylate in aqueous solution). The concentrations were chosen according to a pilot study. Before topical induction "pre-irritation" was induced by Sodium lauryl sulfate solution (10%). No skin reaction was observed in the treated group after the challenge test compared to the controls. Moreover, the test animals' body weight development was examined and they were observed for clinical symptoms. No difference was exhibited between the treated and the control groups. Therefore, it can be concluded that under the test conditions, the test substance tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarboxylate, is not a potential skin sensitiser.
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