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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
(Inhalation hazard test)
Deviations:
yes
Remarks:
(only 6 hours of exposure, only 6 animals of one sex)
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of cyclohexanol and cyclohexanone
EC Number:
906-627-4
Molecular formula:
Unspecified
IUPAC Name:
Reaction mass of cyclohexanol and cyclohexanone

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 260 g

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22
- Humidity (%): 70

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 35 l
Duration of exposure:
6 h
Concentrations:
6.6 mg/l
No. of animals per sex per dose:
6 males
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 6.6 mg/L air
Exp. duration:
6 h
Remarks on result:
other: no mortality occurred
Mortality:
No animals died
Clinical signs:
other: No toxic signs
Body weight:
Day 7: 330 g
Day 14: 390 g
Gross pathology:
Viscera appeared normal

Applicant's summary and conclusion