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EC number: 201-064-4 | CAS number: 77-86-1
Table 1. Individual scores for eye irritation parameters
The acute eye irritation / corrosion study in rabbits was conducted to evaluate the eye irritation potential of Tris Amino Ultra Pure. Under the conditions of this study, Tris Amino Ultra Pure caused conjunctival irritation in the rabbit eye, which cleared by 72 hours.One hundred mg (0.1g) of the test substance was instilled into the conjunctival sac of the left eye of each animal after gently pulling the lower lid away from the eyeball. The lids were gently held together for about one second, in order to minimize loss of the test substance. The right eye of each rabbit remained untreated and served as the reference control. The eyes were evaluated at 1, 24, 48 and 72 hours according to the scale for scoring ocular lesions (DRAIZE, 1977). There were no clinical signs of toxicity or animal deaths. All rabbits appeared healthy and gained body weight throughout the observation period. The test was performed in a stepwise manner. A single rabbit was initially exposed to the test substance. Since the test substance was not corrosive, the study was completed using two additional rabbits.
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