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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption, other
Remarks:
expert statement
Type of information:
other: expert statement
Adequacy of study:
key study
Study period:
2010
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: expert statement
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
The absorption of lithium through skin is considered to be very poor. 10 % absorption was used for DNEL deduction representing a worst case.
Executive summary:

Expert statement: Due to the chemical properties of lithium hydroxide and lithium hydroxide monohydrate, the dermal absorption of these substances at non-corrosive concentrations is expected to be very poor. Based on (1) the hydrophilic character of these substances and (2) the barrier function of the stratum corneum against the respective ions, dermal absorption can practically be excluded. Similar to other lithium salts the acute dermal toxicity of non-corrosive concentrations is expected to be LD50 is > 2000 mg/kg bw as noted for of e.g. lithium carbonate. This also reflects the almost negligible skin penetration of inorganic lithium compounds. 10 % absorption was used for DNEL deduction. Thus, this presents a worst case.

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