Registration Dossier
Registration Dossier
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EC number: 215-183-4 | CAS number: 1310-65-2
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: Case Reports
- Adequacy of study:
- supporting study
- Study period:
- 1982
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Data not sufficient for evaluation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Lithium-Induced Male Sexual Impaired: Two Case Reports
- Author:
- Blay, S.L. et al.
- Year:
- 1 982
- Bibliographic source:
- J. Clin. Psychiatry 43:497-498
Materials and methods
- Study type:
- health record, other
- Remarks:
- Case reports
- Endpoint addressed:
- toxicity to reproduction / fertility
Test guideline
- Qualifier:
- no guideline followed
Test material
- Reference substance name:
- Lithium carbonate
- EC Number:
- 209-062-5
- EC Name:
- Lithium carbonate
- Cas Number:
- 554-13-2
- Molecular formula:
- CH2O3.2Li
- IUPAC Name:
- dilithium carbonate
- Reference substance name:
- Lithium carbonate (case report 1)
- IUPAC Name:
- Lithium carbonate (case report 1)
- Reference substance name:
- Lithium compound not specified, most likely Li2CO3 (case report 2)
- IUPAC Name:
- Lithium compound not specified, most likely Li2CO3 (case report 2)
Constituent 1
Constituent 2
Constituent 3
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Two human case reports exist that led to the notion that lithium could impair male fertility. Male patients (n=2) under lithium therapy (serum levels 18-33 mg/L) complained about reduced libido sexualise and erectile dysfunction. After replacing the lithium by a placebo or after termination of lithium therapy, respectively, recovery of normal sexual functions was reported. This effect is however not surprising as lithium is a psychotropic drug. This effect is therefore not considered as toxic but most likely related secondary to the wished effect of lithium treatment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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