Lead sulfochromate yellow

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: scientifically acceptable study similar to guideline (limit test; non GLP, age of test animals not recorded)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

test substance evaluated at unique 10000 mg/kg dose level

Deviations:

yes

Remarks:

age of test animals not recorded

Principles of method if other than guideline:

BASF-Test

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Chromgelb 62 F

IUPAC Name:

Chromgelb 62 F

Details on test material:

- Name of test material (as cited in study report): chromgelb 62 F (chemical name: lead chromate, -sulfate)
- Physical state: crystal mixture
- Analytical purity: 85% PbCrO4
- Composition of test material, percentage of components: 85% PbCrO4 and 3%, also containing PbSO4, SbF3, Sb2O3 and SiO2 at unspecified percentages

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: SPF breed from WIGA, Sulzfeld
- Age at study initiation: no data
- Weight at study initiation: 205 g for males, 155 for females
- Fasting period before study: no data
- Diet: Altromin-R, Altrogge, Lage/L; ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Details on oral exposure:

VEHICLE (aquous suspension with 0.5% CMC)
Dose (mg/kg bw) /10000
Concentrationof test substance in vehicle (%) /35
Applied volume (ml/kg) /28.57

Doses:

10000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily recording of signs and symptoms from the day of administration till the end of the observation period. Daily check (twice) for moribund and dead animals (once during the weekend).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, pathology.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Remarks on result:

other: no mortality at this unique dose level

Mortality:

no mortality observed

Clinical signs:

other: only feces coloration and urin (yellow) up to day 7 after treatment, nothing abnormal afterwards

Gross pathology:

nothing abnormal detected

Any other information on results incl. tables

Table 1: Body weight

	Mean body weight at)
day after application	0	4	7	14
Males	205	227	246	264
Females	155	170	180	180