Sodium formate

Partition coefficient

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

Version / remarks:

Cited as Directive 92/69/EEC, A.8

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

-2.1

Temp.:

23 °C

pH:

7

Key result

Type:

log Pow

Partition coefficient:

-1.9

Temp.:

23 °C

pH:

5

Key result

Type:

log Pow

Partition coefficient:

-2.3

Temp.:

23 °C

pH:

9

Conclusions:

The log10 partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)

Executive summary:

The log₁₀ partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)

Reference 2

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

30/04/2007

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

other: atomic emission spectroscopy (in duplicate)

Key result

Type:

log Pow

Partition coefficient:

< -1.8

Temp.:

20 °C

pH:

6.5

Flask	pH in water phase	water phase	n-octanol phase	log Pow
1:1	6.5	0.766 mg/mL	<0.012 mg/mL	<-1.8
1:2	6.5	0.773 mg/mL	<0.012 mg/mL	<-1.8
2:1	6.6	0.850 mg/mL	<0.012 mg/mL	<-1.9

The substance was below the limit of detection in the octanol phase. As the concentration was 0.01 M in the water phase, it is not possible to increase the amount of the substance.

Conclusions:

The log10 partition coefficient of sodium formate at 20 °C was measured to be -1.8 (1:1 water octanol ratio), 1.8 (1:2 water octanol ratio), 1.9 (2:1 water octanol ratio).

Executive summary:

The log₁₀ partition coefficient of sodium formate at 20 °C was measured to be -1.8 (1:1 water octanol ratio), 1.8 (1:2 water octanol ratio), 1.9 (2:1 water octanol ratio).

Reference 3

Endpoint:

partition coefficient

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

When added to water both formic acid and sodium formate have similar dissociation constants and will form identical formate ions. Thus a partition coefficient study performed on formic acid will sufficiently address the data requirements of sodium formate.

Reason / purpose for cross-reference:

read-across source

Key result

Type:

log Pow

Partition coefficient:

-2.1

Temp.:

23 °C

pH:

7

Key result

Type:

log Pow

Partition coefficient:

-1.9

Temp.:

23 °C

pH:

5

Key result

Type:

log Pow

Partition coefficient:

-2.3

Temp.:

23 °C

pH:

9

Conclusions:

The log10 partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)

Executive summary:

The log₁₀ partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)

Description of key information

The log₁₀ partition coefficient of formic acid at 23 °C was measured to be -1.9 (pH 5); -2.1 (pH 7); -2.3 (pH 9)

Key value for chemical safety assessment

Log Kow (Log Pow):

-2.1

at the temperature of:

20 °C