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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented, peer-reviewed research study

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VII
Author:
Smyth HF jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA & Nycum JS
Year:
1969
Bibliographic source:
American Industrial Hygiene Association Journal, 1969, Sep-Oct; 30(5):470-6

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The study was performed as part of a series of 'range-finding' tests performed with a large number of industrial chemicals. The protocol for acute oral toxicity is broadly similar to OECD 401 in that groups of rats were intubated with a single dose of the test material and observed for 14 days.
GLP compliance:
no
Remarks:
Pre-GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphuric acid
EC Number:
231-639-5
EC Name:
Sulphuric acid
Cas Number:
7664-93-9
Molecular formula:
H2O4S
IUPAC Name:
sulfuric acid
Test material form:
other: Presumed to be liquid
Details on test material:
95-98% pure (reagent grade sulphuric acid)

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
other: gastric intubation
Vehicle:
unchanged (no vehicle)
Doses:
Not given
No. of animals per sex per dose:
5 females in all were dosed.
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
2 140 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Effect ranged from 1540 to 2990 mg/kgbw

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of this study sulphuric acid demonstrated a low acute oral toxicity when gastric intubation was used as the method of administration. The LD50 by oral administration was calculated to be 2140 mg/kg body weight.