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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: Data Assessment
Adequacy of study:
supporting study
Study period:
2010
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2010

Materials and methods

Objective of study:
toxicokinetics
Test guideline
Qualifier:
no guideline followed
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphamidic acid
EC Number:
226-218-8
EC Name:
Sulphamidic acid
Cas Number:
5329-14-6
Molecular formula:
H3NO3S
IUPAC Name:
sulfamic acid
Test material form:
solid: crystalline
Radiolabelling:
no

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
An at most low absorption in the gastrointestinal tract and through the skin is expected for sulphamidic acid
Type:
metabolism
Results:
Therefore no indication of the importance of the metabolism of the test item

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
Given the very high water solubility and estimated low octanol/water partitioning coefficient, an at most low bioaccumulation is expected. Absorption via oral or dermal exposure is expected being low (both 10% assumed) and based on high particle size inhalation exposure is not relevant (10% absorption assumed as worst case).