Registration Dossier
Registration Dossier
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EC number: 701-480-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Complex metal containing substance
In vivo skin and eye irritation studies indicate that copper slag is not irritating to the skin or eyes.
Solubility of constituents in water is poor
Classification based on rules for mixtures
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The copper slag is a complex metal containing substance. It mainly contains iron silicate and silicates of aluminum and calcium. Traces of metals exist in metal, mineral form or included in silicate phases.
Skin irritation
In a reliable EU B4 method in vivo skin irritation study (Caballero and Alava, 2001) copper slag was applied to the shaved skin of a New Zealand White rabbit under a semiocclusive patch. No formation of erythema and edema observed after 72 h was (score 0.0). Copper slag was found to be non-irritating to the skin in rabbits. The absence of irritation effects furthermore excluded the possibility of corrosion, defined as a serious destruction of tissues throughout the skin thickness.
Eye irritation
In a reliable EU B5 method in vivo eye irritation study (Caballero and Alava, 2001) copper slag was instilled into the eye of a New Zealand White rabbit. No negative changes in cornea, iris, conjuctivae and chemosis were observed after 72 h (score 0.0 ) Copper slag was found to be not eye irritant.
Furthermore classification derivedbased on rules for mixtures:
Skin irritation/corrosion: Not classified
Eye irritation: Not classified
Results from calculated classification are further supported (WoE) by consideration of physical chemical properties of the UVCB substance.
Chemistry and mineralogy of the slag (see IUCLID section 4.23 chemical and mineralogical characterization) were taken into account.
Water solubility (IUCLID section 4.8) and Sequential dissolutions (IUCLID 4.23 Chemical assays) furthermore confirmed species present and their solubility behavior.Copper slag is a solid poorly soluble in water. pH of solution observed in the water solubility test is in the range of 6.1 – 9.9 not extreme like ≤ 2 or ≥ 11.5
Justification for classification or non-classification
In the in vivo skin and eye irritation studies copper slag was non-irritant and therefore does not require classification for skin irritation/corrosion and eye irritation.
Copper slag contains some minor ingredients classified as Skin Corrorsive and .Skin Irritant but these are all present at concentrations < 1% . Therefore copper slag is not classified for skin corrosion and skin irritation.
Copper slag does not contain any constituents classified as Eye Dam.1 . It contains some minor ingredients classified as Eye Irrit. 2 but these are all present at concentrations < 1% . Therefore copper slag is not classified for eye effects.
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