Registration Dossier

Administrative data

Description of key information

Members of the C4 low 1,3-butadiene category are flammable gases at room temperature and therefore the requirement for data on skin and eye irritation is waived in accordance with REACH Annexes VII and VIII (column 2 adaptation). All members of this category are gases, and liquid gases may cause burns and frostbite due to the extreme cold of the liquid.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

In accordance with REACH Annexes VII and VIII column 2 adaptation, studies on skin and eye irritation do not need to be conducted as members of the C4 low 1,3-butadiene category are flammable gases at room temperature

No skin or eye irritation studies have been conducted with streams in this category (CAS Numbers; 91052-98-1, 92045-23-3, 95465-89-7, 95465-90-0 and 95465-91-1) but based on physical chemical properties, the liquid gases may cause burns and frostbite due to the extreme cold of the liquid. There are no data available as no skin or eye irritation studies have been conducted with members of this category but category members are not expected to be irritating. There are no indications of irritation from repeat dose inhalation studies.


Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Members of the C4 low 1,3-butadiene category are flammable gases at room temperature. There is no evidence to suggest that category members are irritating and therefore do not warrant classification under Dir 1999/45/EC or GHS/CLP.