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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Up to 2008

Data source

Referenceopen allclose all

Reference Type:
Reference Type:

Materials and methods

Principles of method if other than guideline:

Results and discussion

Applicant's summary and conclusion

The materiial is likely to be absorbed after ingestion. Metabolism and excretion will include de-esterification and elimination via the urine.
Executive summary:

The substance is a trimellitate ester with linear C8 and C12 alkyl chains. Experimental data are not available for the assessment of the toxicokinetic properties of the C8 -C12 trimellitate and read-across for toxicokinetic property assessment is therefore a possible approach to characterise toxicokinetic endpoints for the substance. Based on structurally similarity to phthalate esters (with two instead of three carboxylic functions) a similar toxicokinetic behaviour can be expected.

Various reviews of different phthalate esters by the Australian National Industrial Chemicals Notification and Assessment Scheme (NICNAS) are available. The data on the toxicokinetics indicate that phthalates in general are likely to be rapidly absorbed as the monoester from the gut and excreted via the urine.