Registration Dossier
Registration Dossier
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EC number: 290-754-9 | CAS number: 90218-76-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Up to 2008
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
- Principles of method if other than guideline:
- N/A
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The materiial is likely to be absorbed after ingestion. Metabolism and excretion will include de-esterification and elimination via the urine.
- Executive summary:
The substance is a trimellitate ester with linear C8 and C12 alkyl chains. Experimental data are not available for the assessment of the toxicokinetic properties of the C8 -C12 trimellitate and read-across for toxicokinetic property assessment is therefore a possible approach to characterise toxicokinetic endpoints for the substance. Based on structurally similarity to phthalate esters (with two instead of three carboxylic functions) a similar toxicokinetic behaviour can be expected.
Various reviews of different phthalate esters by the Australian National Industrial Chemicals Notification and Assessment Scheme (NICNAS) are available. The data on the toxicokinetics indicate that phthalates in general are likely to be rapidly absorbed as the monoester from the gut and excreted via the urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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