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EC number: 220-767-7 | CAS number: 2893-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Short description of key information:
The chlorinated isocyanurates are unstable in the body, particularly the stomach, because the free available chlorine is rapidly reduced. CYA, or its salt, is the stable degradation product. Therefore, CYA, or its sodium salt, is the substance of interest for the reproduction studies.
A 3-generation reproductive study (equivalent to EU Method B.35) showed no biologically detrimental effect on the reproductive potential of the parents or on the growth and development of the offspring.
NOAEL (P): ca. 470 mg/kg bw/day (male)
: ca. 950 mg/kg bw/day (female)
NOAEL (F1): ca. 500 mg/kg bw/day (m)
: ca. 910 mg/kg bw/day (f)
NOAEL(F2): ca. 190 mg/kg bw/day (m)
: ca. 970 mg/kg bw/day (f)
Effects on developmental toxicity
Description of key information
Rodwell (1990), performed according to EPA OPP 83-3 (prenatal developent study) :
NOEL (maternal toxicity): 50 mg/kg bw/day
NOEL (treatogenicity): 500 mg/kg bw/day
There was no evidence of teratogenicity in the absence of maternal toxicity.
Laughlin (1982), performed according to EU Method B.31 (prenatal development study) :
NOAEL (maternal toxicity): 5000 mg /kg bw/day
NOAEL (teratogenicity): 5000 mg/kg bw/day
Test substance was considered non-teratogenic.
Additional information
Maternal Toxicity:
In a study conducted by Rodwell (1990) One female at the 500 mg/kg level and two females at the 50 mg/kg group aborted on gestation days 22, 24 and 26 days respectively. A slight reduction in bodyweight was observed and appeared to correspond with a slight reduction in litter size. However no treatment-related clinical signs of toxicity or gross abnormalities were observed.
In the study conducted by Laughlin (1982),11 females in the high dose sodium control group (5590 mg/kg/day) died between days 8 and 16 of gestation. Survival was 100% in all other groups.The mean maternal body weight in the high dose sodium control group was slightly reduced when compared to the control group.
Developmental Toxicity/ Teratogenicity:
Rodwell (1990), showed that there was a statistically significant increase in post-implantation loss at the 500 mg/kg level. This was primarily related to one dam with 7 late resorptions. No treatment related differences were noted in gravid uterus weight, foetal body weight or foetal malformation data.
In the study conducted by Laughlin (1982), treatment-related effects such as a reduction in group mean foetal body weight and mean foetal crown-rump length and an increase in post-implantation losses were observed in the high-sodium dose group. In the low sodium dose group these parameters were found to be comparable to the controls. In addtion there were some incidences of foetal malformations in the high dose group only.
Justification for classification or non-classification
In the rat teratogenicity study, monosodium cyanurate administered by gavage did not produce a teratogenic response at a dose of 5000 mg/kg bw/day or below. In the rabbit teratogenicity study there was no evidence of developmental toxicity in any of the treated groups.
Oral exposure of monosodium cyanurate in the rat fertility study did not produce any consistent effects on reproductive parameters or offspring toxicity
Additional information
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