Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
other: Mechanistic studies: hepatotoxicity
Rationale for reliability incl. deficiencies:
other: Mechanistic studies: hepatotoxicity

Data source

Referenceopen allclose all

Title:
No information
Author:
Allis, J.W. et al. (1989): Toxicologist 9, 171
Title:
No information
Author:
Allis, J.W. et al. (1992): J. Biochem. Toxicol. 7, 257 - 264
Title:
No information
Author:
Brodie, B.B. et al. (1971): Proc. Nat. Acad. Sci. 68, |160 - 164
Title:
No information
Author:
Gunawardhana, L. et al. (1990): Toxicologist 10, 298
Title:
No information
Author:
Reid, W.D. (1973): Proc. 5th Int. Congr. Pharmacol., |San Francisco 1972, 2, 62 - 74
Title:
No information
Author:
Reid, W.D. et al. (1973): Pharmacology 10, 193 - 214
Title:
No information
Author:
Reid, W.D., Krishna, G. (1973): Exp. Mol. Pathol. 18, |80 - 99
Title:
No information
Author:
Stine, E.R. et al. (1991): Toxicol. Appl. Pharmacol. 109,|472 - 481
Title:
No information
Author:
Umemura T.,et al. (1998):Drug and Chemical Toxicology, 21(1), 57-66 Umemura T, et al.(1996):Toxicology and Applied Pharmacology 137, 268-274 Umemura T., et al.(1992): Arch.Toxicol.66: 503-507

Materials and methods

Type of study / information:
Type: other: Hepatoxicity
Principles of method if other than guideline:
other: Mechanistic studies: hepatotoxicity
GLP compliance:
not specified
Remarks:
other: Mechanistic studies: hepatotoxicity

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dichlorobenzene
EC Number:
203-400-5
EC Name:
1,4-dichlorobenzene
Cas Number:
106-46-7
Molecular formula:
C6H4Cl2
IUPAC Name:
1,4-dichlorobenzene
Details on test material:
other: Mechanistic studies: hepatotoxicity

Results and discussion

Any other information on results incl. tables

other: Mechanistic studies: hepatotoxicity

Applicant's summary and conclusion

Executive summary:

other: Mechanistic studies: hepatotoxicity