Registration Dossier
Registration Dossier
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EC number: 203-854-4 | CAS number: 111-29-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies in Detoxication - The Metabolism of Glycols
- Author:
- Gessner PK, Parke DV and Williams RT
- Year:
- 1 960
- Bibliographic source:
- Biochem. J. 74: 1-5
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentane-1,5-diol
- EC Number:
- 203-854-4
- EC Name:
- Pentane-1,5-diol
- Cas Number:
- 111-29-5
- Molecular formula:
- C5H12O2
- IUPAC Name:
- pentane-1,5-diol
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- Chinchilla
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2 - 3 kg
- Diet (e.g. ad libitum): 60 g of rat cubes (diet 41 ; Associated London Flour Milers) per day
- Water (e.g. ad libitum): 100 ml water, per day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.75 g/kg bw; 2 mmol/kg bw
- No. of animals per sex per dose / concentration:
- 4 animals
- Control animals:
- no
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- metabolite glutaric acid
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- glutaric acid
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
