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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
March 15 to July 5, 1996
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Full study not yet available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Type of assay:
bacterial gene mutation assay

Test material

Constituent 1
Reference substance name:
Phosphorus tribromide
EC Number:
232-178-2
EC Name:
Phosphorus tribromide
Cas Number:
7789-60-8
IUPAC Name:
phosphorus(3+) tribromide

Results and discussion

Test results
Species / strain:
S. typhimurium, other: unspecified
Metabolic activation:
not specified
Genotoxicity:
negative

Applicant's summary and conclusion

Conclusions:
Genotoxicity testing of bacterial Salmonella strains indicated that PBr3 is not a mutagen for both frame shift and base-pair substitution tester strains in both buffered and unbuffered solutions. PBr3 reacts with moisture to form HBr and phosphonic acid. Thus, it is not likely that HBr is a bacterial mutagen.
Executive summary:

Genotoxicity testing of bacterial Salmonella strains indicated that PBr3 is not a mutagen for both frame shift and base-pair substitution tester strains in both buffered and unbuffered solutions. PBr3 reacts with moisture to form HBr and phosphonic acid. Thus, it is not likely that HBr is a bacterial mutagen.