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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The result is considered to be reliable for determination of classification.

Data source

Reference
Reference Type:
publication
Title:
I. Experimental study - Cutaneous burns in rats induced by hydrochloric acid, hydrobromic and hydroiodic acids.
Author:
Quevauviller, A. et al.
Year:
1974
Bibliographic source:
Annales Pharmaceutiques Françaises, Vol. 32, Iss. 7-8, pp. 421-5

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Evaluation and measurement of burns caused by application of hydrogen bromide (HBr), hydrogen iodide (HI) and hydrogen chloride (HCl) to rat skin.

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrogen bromide
EC Number:
233-113-0
EC Name:
Hydrogen bromide
Cas Number:
10035-10-6
Molecular formula:
BrH
IUPAC Name:
bromide
Details on test material:
Hydrobromic acid

Test animals

Species:
rat

Results and discussion

In vivo

Results
Irritation parameter:
other: necrosis
Basis:
mean
Reversibility:
not reversible

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
HBr causes more severe burns to rat skin than HCl or HI.
Executive summary:

HBr causes more severe burns to rat skin than HCl or HI.