Registration Dossier
Registration Dossier
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EC number: 233-113-0 | CAS number: 10035-10-6
Endpoint summary
Administrative data
Description of key information
Kraut, A., and Lilas, R. (1988) report accidental exposure to vapors from a mixture of hydrogen bromide (HBr) and phosphorus tribromide (PBr3) causing chemical pneumonitis, and a protracted illness. Transbronchial biopsy at 10 months showed fibrosis consistent with bronchiolitis obliterans, a potentially fatal complication of toxic irritant gas exposure.
Human inhalation is summarized in the HSDB for HBr. Nose and throat irritation occurred in human subjects exposed to HBr for several minutes at concentrations of 3 ppm (1 of 6 subjects) and 4 ppm (3 of 6 subjects) respectively for several minutes. No effects were observed at 2 ppm, but detectable odor was noted at all exposure levels (2 to 6 ppm). No eye irritation was noted at all concentrations exposed. The odour threshold is given as 6.667 mg/m3 and the irritating concentration as 10.00 mg/m3.
Additional information
Kraut, A., and Lilas, R. (1988) report accidental exposure to vapors from a mixture of HBr and PBr3 causing chemical pneumonitis, and a protracted illness. Transbronchial biopsy at 10 months showed fibrosis consistent with bronchiolitis obliterans, a potentially fatal complication of toxic irritant gas exposure.
Human inhalation is summarized in the HSDB for HBr. Nose and throat irritation occurred in human subjects exposed to HBr for several minutes at concentrations of 3 ppm (1 of 6 subjects) and 4 ppm (3 of 6 subjects) respectively for several minutes. No effects were observed at 2 ppm, but detectable odor was noted at all exposure levels (2 to 6 ppm). No eye irritation was noted at all concentrations exposed. The odour threshold is given as 6.667 mg/m3 and the irritating concentration as 10.00 mg/m3.
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